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Adaptation of therapy

IMPACT Team: Image and models for the adaptation of therapy

The objective is to devise, integrate, implement and evaluate efficient decision support approaches consistent with clinical constraints. This research axis relies on the outcomes of the work mentioned above. Even if some contributions are at the pre-clinical level, solutions proposed and developed in this research axis are close to clinical application and evaluation.

Navigation and augmented tracking (devices, structures)



Augmented endovascular navigation: a) comparison between the real intraoperative shape of the vascular structure deformed by guidewires and the deformed shape given by the simulation, highlighting the existence of folds on the wall in both cases, b) Intra-operative fluroscopic images augmented with the visualization of the deformed structure and the stent-graft

PhD of:
  • LH. Nguyen-Duc. Tracking De Dispositifs Et De Structures Pour Le Traitement Endovasculaire Des Pathologies Aortiques.
  • R. Belhaj-Soulami. Computer assistance in valve-in-valve procedures.
  • Z. Sandoval. Planning Et Guidage D'une Thérapie De L'arythmie Cardiaque Par Ultrasons Focalisés.
  • B. Dahman. Planning and guidance of HIFU therapy for ventricular fibrillation.
  • J. Shen. Framework for Ultrasonography-Based Augmented Reality in Robotic Surgery: Application to Transoral Surgery and Gastrointestinal Surgery.

Selected publications:

  • Dahman, B. and Dillenseger, J. HIFU Therapy Guidance System by Image-based Registration for Patients with Cardiac Fibrillation. in Computing in Cardiology. 2019.
  • Daoudal A, Gindre J, Lalys F, Kafi M, Dupont C, Lucas A, Haigron P, Kaladji A. Use of Numerical Simulation to Predict Iliac Complications During Placement of an Aortic Stent Graft. Annals of Vascular Surgery. 2019 Nov;61:291-8.
  • Dumenil A, Kaladji A, Castro M, Goksu C, Lucas A, Haigron P. A Versatile Intensity-Based 3d/2d Rigid Registration Compatible with Mobile C-Arm for Endovascular Treatment of Abdominal Aortic Aneurysm. International Journal of Computer Assisted Radiology and Surgery. 2016 Sep;11(9):1713-29.
  • Kaladji A, Dumenil A, Mahe G, Castro M, Cardon A, Lucas A, Haigron P. Safety and Accuracy of Endovascular Aneurysm Repair without Pre-Operative and Intra-Operative Contrast Agent. European Journal of Vascular and Endovascular Surgery. 2015 Mar;49(3):255-61.
  • Kaladji A, Daoudal A, Clochard E, Gindre J, Cardon A, Castro M, Haigron P, Lucas A. Interest of Fusion Imaging and Modern Navigation Tools with Hybrid Rooms in Endovascular Aortic Procedures. Journal of Cardiovascular Surgery. 2017 Jun;58(3):458-66.
  • Kaladji A, Villena A, Pascot R, Lalys F, Daoudal A, Clochard E, Lucas A, Cardon A. Fusion Imaging for Evar with Mobile C-Arm. Annals of Vascular Surgery. 2019 Feb;55:166-74.
  • Peyronnet B, …, Mathieu R, …, Bensalah K, French Com Urologic O. Comparison of 1800 Robotic and Open Partial Nephrectomies for Renal Tumors. Annals of Surgical Oncology. 2016 Dec;23(13):4277-83.
  • Sandoval Z, Castro M, Alirezaie J, Bessiere F, Lafon C, Dillenseger JL. Transesophageal 2d Ultrasound to 3d Computed Tomography Registration for the Guidance of a Cardiac Arrhythmia Therapy. Physics in Medicine and Biology. 2018 Aug;63(15):13.
  • Shen J, Zemiti N, Taoum C, Aiche G, Dillenseger JL, Rouanet P, Poignet P. Transrectal Ultrasound Image-Based Real-Time Augmented Reality Guidance in Robot-Assisted Laparoscopic Rectal Surgery: A Proof-of-Concept Study. International Journal of Computer Assisted Radiology and Surgery. 2020 Mar;15(3):531-43.
  • Soulami RB, Verhoye JP, Duc N, Castro M, Auffret V, Anselmi A, Haigron P, Ruggieri VG. Computer-Assisted Transcatheter Heart Valve Implantation in Valve-in-Valve Procedures. Innovations-Technology and Techniques in Cardiothoracic and Vascular Surgery. 2016 May-Jun;11(3):193-200.
  • Soulami RB, Castro M, Haigron P, Verhoye JP. Structural valve deterioration does not alter tissue valves' radiopaque landmarks: Implications for valve-in-valve therapy. Medical Hypotheses. 2019 Jun; 127:49-56.

Decision support for cardio-thoracic interventions

PhD of:
  • V. Auffret. Aide À La Décision Dans Le Remplacement Valvulaire Aortique Percutané.
  • S. Rouzé. Intraoperative imaging-based nodule location in Video-assisted thoracoscopic surgery.
  • P. Alvarez Corrales. Lung deformation estimation using a hybrid image based/biomechanics-based approach for the localization of pulmonary nodules during video-assisted thoracoscopic surgery.
  • A. Anselmi. Ajustement Anatomique Des Dispositifs D’assistance Cardiaque Mécanique De Longue Durée Par Exploitation De L’imagerie Et De La Simulation.
  • S. Collin. Preoperative Planning and Simulation for Artificial Heart Implantation Surgery.
  • A. Ben Abid. Hemodynamic simulation for the implantation of mechanical circulatory support devices.

Selected publications:

  • Alvarez, P., Rouzé, S., Miga, M. I., Payan, Y., Dillenseger, J. L., Chabanas, M. A hybrid, image-based and biomechanics-based registration approach to markerless intraoperative nodule localization during video-assisted thoracoscopic surgery. Medical Image Analysis, 2021, 101983.
  • Alvarez P, Narasimhan S, Rouze S, Dillenseger JL, Payan Y, Miga MI, Chabanas M. Biphasic Model of Lung Deformations for Video-Assisted Thoracoscopic Surgery Proceedings of the IEEE16th International Symposium on Biomedical Imaging (ISBI); 2019; New York, USA. Ieee;  p. 1367-71.
  • Anselmi A, Collin S, Haigron P, Verhoye JP, Flecher E. Virtual Implantation of a Novel Lvad: Toward Computer-Assisted Surgery for Heart Failure. Journal of Surgical Research. 2016 Sep;205(1):204-7.
  • Anselmi A, Collin S, Haigron P, Verhoye JP, Flecher E. Device-Specific Evaluation of Intraventricular Left Ventricular Assist Device Position by Quantitative Coaxiality Analysis. Journal of Surgical Research. 2017 Jun;213:110-4.
  • Auffret V, Regueiro A, Del Trigo M, Altisent OAJ, Campelo-Parada F, Chiche O, Puri R, Rodes-Cabau J. Predictors of Early Cerebrovascular Events in Patients with Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement. Journal of the American College of Cardiology. 2016 Aug;68(7):673-84.
  • Auffret V, …, Verhoye JP, …, Boulmier D, …, Le Breton H, Investigators FT. Temporal Trends in Transcatheter Aortic Valve Replacement in France France 2 to France Tavi. Journal of the American College of Cardiology. 2017 Jul;70(1):42-55.
  • Auffret V, Puri R, Urena M, Chamandi C, Rodriguez-Gabella T, Philippon F, Rodes-Cabau J. Conduction Disturbances after Transcatheter Aortic Valve Replacement Current Status and Future Perspectives. Circulation. 2017 Sep;136(11):1049-+.
  • Di Perna D, Castro M, Gasc Y, Haigron P, Verhoye JP, Anselmi A. Patient-Specific Access Planning in Minimally Invasive Mitral Valve Surgery. Medical Hypotheses. 2020 Mar;136:7.
  • Feuillatre H, Auffret V, Castro M, Lalys F, Le Breton H, Garreau M, Haigron P. Similarity Measures and Attribute Selection for Case-Based Reasoning in Transcatheter Aortic Valve Implantation. Plos One. 2020 Sep;15(9):21.
  • Li H, Castro M, Haigron P, Verhoye JP, Ruggieri VG. Decision Support System for the Planning of Minimally Invasive Aortic Valve Replacement Surgery. International Journal of Computer Assisted Radiology and Surgery. 2018 Aug;13(8):1245-55.
  • Rouze S, de Latour B, Flecher E, Guihaire J, Castro M, Corre R, Haigron P, Verhoye JP. Small Pulmonary Nodule Localization with Cone Beam Computed Tomography During Video-Assisted Thoracic Surgery: A Feasibility Study. Interactive Cardiovascular and Thoracic Surgery. 2016 Jun;22(6):705-11.

Monitoring and adaptation of the treatment in radiation therapy

PhD of:
  • M. Nassef. Dose monitoring for adaptive radiation therapy of prostate cancer.
  • J. Castelli. Morphological and metabolical adaptive radiation therapy for head-and-neck cancers.
  • B. Rigaud. Adaptive radiation therapy guided by anatomical imaging.



Dose monitoring in deformable organs at risk. Estimation of the deviation between the dose planned from the pre-treatment CT and the dose cumulated from the non-rigid registration of per-treatment CBCT images.


Selected publications:

  • Barateau A, De Crevoisier R, Largent A, Mylona E, Perichon N, Castelli J, Chajon E, Acosta O, Simon A, Nunes JC, Lafond C. Comparison of Cbct-Based Dose Calculation Methods in Head and Neck Cancer Radiotherapy: From Hounsfield Unit to Density Calibration Curve to Deep Learning. Medical Physics. 2020 Epub:11.
  • Castelli J, Simon A, Louvel G, Henry O, Chajon E, Nassef M, Haigron P, Cazoulat G, Ospina JD, Jegoux F, Benezery K, De Crevoisier R. Impact of Head and Neck Cancer Adaptive Radiotherapy to Spare the Parotid Glands and Decrease the Risk of Xerostomia. Radiation Oncology. 2015 Jan;10:10.
  • Castelli J, Simon A, Rigaud B, Lafond C, Chajon E, Ospina JD, Haigron P, Laguerre B, Loubiere AR, Benezery K, De Crevoisier R. A Nomogram to Predict Parotid Gland Overdose in Head and Neck Imrt. Radiation Oncology. 2016 Jun;11:11.
  • Castelli J, Simon A, Rigaud B, Chajon E, Thariat J, Benezery K, Vauleon E, Jegoux F, Henry O, Lafond C, De Crevoisier R. Adaptive Radiotherapy in Head and Neck Cancer Is Required to Avoid Tumor Underdose. Acta Oncologica. 2018;57(9):1267-70.
  • De Crevoisier R, …, Lagrange JL. Daily Versus Weekly Prostate Cancer Image Guided Radiation Therapy: Phase 3 Multicenter Randomized Trial. International Journal of Radiation Oncology Biology Physics. 2018 Dec;102(5):1420-9.
  • Nassef M, Simon A, Cazoulat G, Dumenil A, Blay C, Lafond C, Acosta O, Balosso J, Haigron P, De Crevoisier R. Quantification of Dose Uncertainties in Cumulated Dose Estimation Compared to Planned Dose in Prostate Imrt. Radiotherapy and Oncology. 2016 Apr;119(1):129-36.
  • Rigaud B, Simon A, Castelli J, Gobeli M, Arango JDO, Cazoulat G, Henry O, Haigron P, De Crevoisier R. Evaluation of Deformable Image Registration Methods for Dose Monitoring in Head and Neck Radiotherapy. Biomed Research International. 2015;2015:16.
  • Rigaud B, Simon A, Gobeli M, Lafond C, Leseur J, Barateau A, Jaksic N, Castelli J, Williaume D, Haigron P, De Crevoisier R. Cbct-Guided Evolutive Library for Cervical Adaptive Imrt. Medical Physics. 2018 Apr;45(4):1379-90.
  • Rigaud B, Simon A, Castelli J, Lafond C, Acosta O, Haigron P, Cazoulat G, De Crevoisier R. Deformable Image Registration for Radiation Therapy: Principles, Methods, Applications and Evaluation. Acta Oncologica. 2019 Sep;58(9):1225-37.
  • Rigaud B, Simon A, Gobeli M, Leseur J, Duverge L, Williaume D, Castelli J, Lafond C, Acosta O, Haigron P, De Crevoisier R. Statistical Shape Model to Generate a Planning Library for Cervical Adaptive Radiotherapy. IEEE Transactions on Medical Imaging. 2019 Feb;38(2):406-16.
  • Simon A, Le Maitre A, Nassef M, Rigaud B, Castelli J, Acosta O, Haigron P, Lafond C, De Crevoisier R. Is Dose Deformation-Invariance Hypothesis Verified in Prostate Igrt? International Journal of Radiation Oncology Biology Physics. 2017 Mar;97(4):830-8.
  • Zhang PC, Simon A, Rigaud B, Castelli J, Arango JDO, Nassef M, Henry O, Zhu J, Haigron P, Li BS, Shu HZ, De Crevoisier R. Optimal Adaptive Imrt Strategy to Spare the Parotid Glands in Oropharyngeal Cancer. Radiotherapy and Oncology. 2016 Jul;120(1):41-7.